Hi Gregory,
Short answer, Yes.
Long answer, I did just this with a Soviet Draisine “Krasnaja Zvezda” kit from Hobby Boss. I built it so I can remove the 1/72 carriage and trucks and assemble it on top of n HO Track Cleaner.
https://forums.kitmaker.net/t/soviet-draisine-krasnaja-zvezda-1-72-oob-and-kitmash-conversion/2094
The entire WIP BLog link is at the top of the first post there.